Categories: Drugs

Proton pump inhibitor (PPI) Uses, Side Effects in Details

Are you searching for Proton pump inhibitor drugs? Here we have described all the side effects, uses and all other information about Proton pump inhibitor

What is a proton pump inhibitor?

Proton pump inhibitors are the drugs, those are having the main action of pronounced and long-lasting reduction of stomach acid production.

Mechanism of action of proton pump Inhibitors

The various mechanism of action of proton pump inhibitors(ppis) are followingly

Proton pump inhibitors reduce the secretion/production of acid, they block the enzymes(those are secreting) in the wall of the stomach those secrets acid.

In esophagus, stomach, and duodenum the formation of most ulcers caused by the excess secretion of acid.

Proton pump inhibitors(ppis) prevent ulcers and proton pump inhibitors allow ulcers to heal those are exists in esophagus, stomach, and duodenum.

Drugs interacting with proton pump inhibitors

There are some drugs those reacts with the proton pump inhibitors inside body

When some drugs absorbed into the body in the presence of acid in the stomach, the proton pump inhibitors reduces in the stomach and they may affect the absorption of drugs and proton pump inhibitors reduces the absorption and concentration.

In the blood ketoconazole (Nizoral) and increase the absorption and concentration of digoxin (Lanoxin), and then it leads to reduce the effectiveness of ketoconazole and this leads to an increase in digoxin toxicity.

The proton pump inhibitors can reduce the breakdown of some drugs by the liver and it leads to an increase in their concentration in the blood
Omeprazole (Prilosec)drug is more likely than other proton pump inhibitors to reduce the breakdown of the drugs by the liver.
The omeprazole (Prilosec) drug may increase the concentration in blood of diazepam (valium), warfarin (Coumadin), phenytoin(Dilantin)
Omeprazole (Prilosec/Prilosec OTC(over the counter) ) reduces the effects of clopidogrel(Plavix) by blocking the conversion of clopidogrel to its active form, this combination should be avoided.

List of examples of the brands and their generic names for proton pump inhibitors

There are some examples of proton pump
Inhibitors with the brands including their generic names

  • Omeprazole (Prilosec/Prilosec OTC)
  • Aspirin and omeoprazole (yosprala)
  • Lansoprazole(Prevacid, Prevacid iv, Prevacid 24 hours)
  • Dexlansoprazole(dexilent, dexilent solutab)
  • Rabeprazole(aciphex, aciphex sprinkle)
  • Pantoprazole(protonix)
  • Esomeprazole(medium, medium iv, nexium24hour)
  • Esomeprazole magnesium/naproxen(vimovo)
  • Omeoprazole/sodium bicarbonate

What is acid reflux or GERD?

Generally, naturally, the stomach makes acid to help you digest foods and remove the bacteria.
It is a natural process, but if more acid secretion occurs then it causes discomfort, the general symptoms related to this area:

  1. Burning chest
  2. Regurgitating(bringing up) acid in the mouth and throat
  3. Seizing lump in your throat when swallowing
  4. Burping
  5. Bloating or filling fullness in the stomach
  6. Hiccups
  7. Coughing
  8. Chest pain

Diseases those proton pump inhibitors treat

Proton pump inhibitors are used for the treatment and prevention of acid-related diseases such as
Ulcers in esophagus duodenal and stomach ulcers

Nasaid -associated with ulcers

Details are following

Gastroesophageal reflux disease (GERD) is also known as :-
Zollinger-ellison syndrome
Also, they are used in combination with antibiotics for eradicating the bacteria known as Helicobacter pylori
A bacterium that together with acid causes ulcers of the stomach and duodenum
Cs for eradicating H. Pylori  is a bacterium that together with acid causes ulcers of the stomach and duodenum
All the proton pump inhibitors are not similar in action And also no one differs from another, the only difference is seen that how they are broken down by the liver and their drug interactions
Some  of the proton pump inhibitors are having last longer effects and some of them are also having less frequent Side effects

The side effects of proton pump inhibitors are as follows

The general side effects of proton pump inhibitors (ppis) are followings
  • Headache
  • Diarrhea
  • Constipation
  • Abdominal pain
  • Flatulence
  • Fever
  • Vomiting
  • Nausea
  • Rash

The proton pump inhibitors are an increase risk of CLOSTRIDIUM difficult infection of the colon
High dose and long term use ( may be it is 1yr or longer) may increase the risk of osteoporosis-related fractures of the hip, wrist or spine, prolonged use also reduces the absorption of vitamin:-b12 (cyanocobalamin)
Long term use of proton pump inhibitors has also been associated with low levels of magnesium (hypomagnesemia)
Analysis of those patients those are having long term use of proton pump inhibitors leads to heart attack
So use of the lowest doses and shortest duration of treatment as necessary as directed by the doctor/physicians

Other side effects

The other side effects are followed

  1. Serious allergic reactions
  2. Steven Johnson syndrome
  3. Toxic epidermal necrolysis
  4. Reduced kidney function
  5. Pancreatitis
  6. Reduced liver function
  7. Erythema multiforme

Best proton pump inhibitor medication

The types of proton pump inhibitors are as follows in details

There are 2 types of best medications known that are omeprazole (Prilosec) and esomeprazole (medium)
Both are available on over the counter (OTC) drug


Proton pump inhibitors increase the risk of serious gout infections

A 2016 study regarding this showed that use of proton pump inhibitors was associated with a 1.7times increases the risk of campylobacter infection
Those patients are having with chronic bowel problems who used proton pump inhibitors had an even greater risk


It’s should not be used for more than 2 weeks unless you are told to do so by the Healthcare provider or doctor or physicians

Can Proton pump inhibitors make GERD worse?

Sometimes your stomach will make a higher than normal amount of acid secretion before lastly constrictive of two regular levels studies have shown that Proton pump inhibitors can cause reflux symptoms in people who did not have them before when the tried to quite them suddenly then it happens

Does Proton pump inhibitors cause weight gain?

The patients those are having GERD open use acid-suppressing medications the most potent of which are Proton pump inhibitors (PPIs),however, Proton pump inhibitors use is costly and has been associated with a number of potential risks recently there has been data to suggest that long term Proton pump inhibitors use leads to weight gain. So at first cosult your doctor or pharmacist about the use of proton pump inhibitors (ppis) after that use as directed

How quickly do Proton pump inhibitors are works?

Proton pump inhibitors decrease stomach acid  secretion over a for to 12 week period this amount of time also allows for proper healing of the esophagus tissue it may take longer for a Proton pump inhibitor To heal your symptoms than an H2 receptor blocker which usually starts reducing chronic acid within one hour


The majority of the patients respond to a single daily dose of a Proton pump inhibitor for had gone for Reflux symptoms but some will require twice-daily dosing  it is only if the physicians or pharmacists prescribed as so

Do you need to stop Proton pump inhibitor before endoscopy?

In some cases, if endoscopy being performed screen for Barrett’s Ashok fibers then it is recommended that the patient remains on a Proton pump inhibitor for at least 8 weeks before the endoscopy.

This is Done in an effort to eliminate  any erosive esophagitis

Stoping the proton pump inhibitors is unlikely  to results in harm to the patient some times

Do Proton pump inhibitors affect digestion?

Proton pump inhibitors impair the hydrolytic digestion by inhibition still dependent peptic activity thereby delaying the solid emptying it may have the clinical implications in the management of Gastroesophageal reflux disease
Functional dyspepsia
As well as diabetes
It does so

Can anyone drink alcohol while taking Proton pump inhibitors?

No, you cannot because some side effect appears dehydration and low sodium levels

Can Proton pump inhibitors cause Gastritis?

The profound acid suppression by Proton pump inhibitors what is shown to be associated with masking h pylori infection the main cause of chronic active gastritis and peptic ulcer disease however atrophic gastritis a prominent risk factor for gastric cancer remains the most serious complication

Medications do and don’t

You should have follow the medications as directed by the physicians/doctors

Take Proton pump inhibitors on an empty stomach and eat something 30 to 45 minutes later
Take Proton pump inhibitors first thing in the morning only told otherwise by your doctor if you are instructed to take a Proton pump inhibitor twice daily take the second dose before dinner, not at bedtime

What is the best Proton pump inhibitor for GERD?

Proton pump inhibitors are considered the most effective therapy For GERD
Due to their profound and consistent acid suppression.
The first compound in this class of drugs Omeprazole was introduced in the year 1918 century

How often take Proton pump Inhibitors?

There are some patients have Acid Reflux may need to take Proton pump inhibitors every day and some others May control symptoms with a Proton pump inhibitors every day.
If you have a peptic ulcer, your doctor may prescribe Proton pump inhibitors along with two or three other medications for up to 2 weeks

Proton pump inhibitors dangerous or not?

Sometimes Proton pump inhibitors may leads to death risk
According to a study in July 3, 2017
Popular heartburn drugs known as Proton pump inhibitors may raise the chance of death what is the new research shows it is not the first time the drugs also known as Proton pump inhibitors have been linked to death dangerous

Which is better H2 blocker on proton pump inhibitor?

Proton pump inhibitor more effective than H2 blocker because there more often to use to treat chronic symptoms of heartburn  so  the protons pump inhibitors are best for use rather than H2blockers

Is Dexilant better than Omeprazole?

Prilosec Omeprazole
Dexilent  dexlansoprazole is a effective medicine which is used to treat heartburn but it can be very expensive since it is only available as a brand
Treats heartburn and excess release of stomach acid secretion
Prilosec omeoprazole gives you the long lasting heartburn relief but  it generally has some risks if used it for long time


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