Are you searching for Proton pump inhibitor drugs? Here we have described all the side effects, uses and all other information about Proton pump inhibitor
What is a proton pump inhibitor?
Proton pump inhibitors are the drugs, those are having the main action of pronounced and long-lasting reduction of stomach acid production.
Mechanism of action of proton pump Inhibitors
Proton pump inhibitors reduce the secretion/production of acid, they block the enzymes(those are secreting) in the wall of the stomach those secrets acid.
In esophagus, stomach, and duodenum the formation of most ulcers caused by the excess secretion of acid.
Proton pump inhibitors(ppis) prevent ulcers and proton pump inhibitors allow ulcers to heal those are exists in esophagus, stomach, and duodenum.
Drugs interacting with proton pump inhibitors
When some drugs absorbed into the body in the presence of acid in the stomach, the proton pump inhibitors reduces in the stomach and they may affect the absorption of drugs and proton pump inhibitors reduces the absorption and concentration.
In the blood ketoconazole (Nizoral) and increase the absorption and concentration of digoxin (Lanoxin), and then it leads to reduce the effectiveness of ketoconazole and this leads to an increase in digoxin toxicity.
The proton pump inhibitors can reduce the breakdown of some drugs by the liver and it leads to an increase in their concentration in the blood
Omeprazole (Prilosec)drug is more likely than other proton pump inhibitors to reduce the breakdown of the drugs by the liver.
The omeprazole (Prilosec) drug may increase the concentration in blood of diazepam (valium), warfarin (Coumadin), phenytoin(Dilantin)
Omeprazole (Prilosec/Prilosec OTC(over the counter) ) reduces the effects of clopidogrel(Plavix) by blocking the conversion of clopidogrel to its active form, this combination should be avoided.
List of examples of the brands and their generic names for proton pump inhibitors
There are some examples of proton pump
Inhibitors with the brands including their generic names
- Omeprazole (Prilosec/Prilosec OTC)
- Aspirin and omeoprazole (yosprala)
- Lansoprazole(Prevacid, Prevacid iv, Prevacid 24 hours)
- Dexlansoprazole(dexilent, dexilent solutab)
- Rabeprazole(aciphex, aciphex sprinkle)
- Esomeprazole(medium, medium iv, nexium24hour)
- Esomeprazole magnesium/naproxen(vimovo)
- Omeoprazole/sodium bicarbonate
What is acid reflux or GERD?
Generally, naturally, the stomach makes acid to help you digest foods and remove the bacteria.
It is a natural process, but if more acid secretion occurs then it causes discomfort, the general symptoms related to this area:
- Burning chest
- Regurgitating(bringing up) acid in the mouth and throat
- Seizing lump in your throat when swallowing
- Bloating or filling fullness in the stomach
- Chest pain
Diseases those proton pump inhibitors treat
Proton pump inhibitors are used for the treatment and prevention of acid-related diseases such as
Ulcers in esophagus duodenal and stomach ulcers
Nasaid -associated with ulcers
Gastroesophageal reflux disease (GERD) is also known as :-
Also, they are used in combination with antibiotics for eradicating the bacteria known as Helicobacter pylori
A bacterium that together with acid causes ulcers of the stomach and duodenum
Cs for eradicating H. Pylori is a bacterium that together with acid causes ulcers of the stomach and duodenum
All the proton pump inhibitors are not similar in action And also no one differs from another, the only difference is seen that how they are broken down by the liver and their drug interactions
Some of the proton pump inhibitors are having last longer effects and some of them are also having less frequent Side effects
The side effects of proton pump inhibitors are as follows
- Abdominal pain
The proton pump inhibitors are an increase risk of CLOSTRIDIUM difficult infection of the colon
High dose and long term use ( may be it is 1yr or longer) may increase the risk of osteoporosis-related fractures of the hip, wrist or spine, prolonged use also reduces the absorption of vitamin:-b12 (cyanocobalamin)
Long term use of proton pump inhibitors has also been associated with low levels of magnesium (hypomagnesemia)
Analysis of those patients those are having long term use of proton pump inhibitors leads to heart attack
So use of the lowest doses and shortest duration of treatment as necessary as directed by the doctor/physicians
Other side effects
The other side effects are followed
- Serious allergic reactions
- Steven Johnson syndrome
- Toxic epidermal necrolysis
- Reduced kidney function
- Reduced liver function
- Erythema multiforme
Best proton pump inhibitor medication
There are 2 types of best medications known that are omeprazole (Prilosec) and esomeprazole (medium)
Both are available on over the counter (OTC) drug
PROTON PUMP INHIBITORS ARE GOOD OR NOT
Proton pump inhibitors increase the risk of serious gout infections
A 2016 study regarding this showed that use of proton pump inhibitors was associated with a 1.7times increases the risk of campylobacter infection
Those patients are having with chronic bowel problems who used proton pump inhibitors had an even greater risk
HOW LONG YOU SHOULD TAKE PROTON PUMP INHIBITORS
It’s should not be used for more than 2 weeks unless you are told to do so by the Healthcare provider or doctor or physicians
Can Proton pump inhibitors make GERD worse?
Sometimes your stomach will make a higher than normal amount of acid secretion before lastly constrictive of two regular levels studies have shown that Proton pump inhibitors can cause reflux symptoms in people who did not have them before when the tried to quite them suddenly then it happens
Does Proton pump inhibitors cause weight gain?
The patients those are having GERD open use acid-suppressing medications the most potent of which are Proton pump inhibitors (PPIs),however, Proton pump inhibitors use is costly and has been associated with a number of potential risks recently there has been data to suggest that long term Proton pump inhibitors use leads to weight gain. So at first cosult your doctor or pharmacist about the use of proton pump inhibitors (ppis) after that use as directed
How quickly do Proton pump inhibitors are works?
Proton pump inhibitors decrease stomach acid secretion over a for to 12 week period this amount of time also allows for proper healing of the esophagus tissue it may take longer for a Proton pump inhibitor To heal your symptoms than an H2 receptor blocker which usually starts reducing chronic acid within one hour
CAN YOU TAKE PROTON PUMP INHIBITORS TWICE?
The majority of the patients respond to a single daily dose of a Proton pump inhibitor for had gone for Reflux symptoms but some will require twice-daily dosing it is only if the physicians or pharmacists prescribed as so
Do you need to stop Proton pump inhibitor before endoscopy?
This is Done in an effort to eliminate any erosive esophagitis
Stoping the proton pump inhibitors is unlikely to results in harm to the patient some times
Do Proton pump inhibitors affect digestion?
Proton pump inhibitors impair the hydrolytic digestion by inhibition still dependent peptic activity thereby delaying the solid emptying it may have the clinical implications in the management of Gastroesophageal reflux disease
As well as diabetes
It does so
Can anyone drink alcohol while taking Proton pump inhibitors?
No, you cannot because some side effect appears dehydration and low sodium levels
Can Proton pump inhibitors cause Gastritis?
The profound acid suppression by Proton pump inhibitors what is shown to be associated with masking h pylori infection the main cause of chronic active gastritis and peptic ulcer disease however atrophic gastritis a prominent risk factor for gastric cancer remains the most serious complication
Medications do and don’t
Take Proton pump inhibitors on an empty stomach and eat something 30 to 45 minutes later
Take Proton pump inhibitors first thing in the morning only told otherwise by your doctor if you are instructed to take a Proton pump inhibitor twice daily take the second dose before dinner, not at bedtime
What is the best Proton pump inhibitor for GERD?
Proton pump inhibitors are considered the most effective therapy For GERD
Due to their profound and consistent acid suppression.
The first compound in this class of drugs Omeprazole was introduced in the year 1918 century
How often take Proton pump Inhibitors?
There are some patients have Acid Reflux may need to take Proton pump inhibitors every day and some others May control symptoms with a Proton pump inhibitors every day.
If you have a peptic ulcer, your doctor may prescribe Proton pump inhibitors along with two or three other medications for up to 2 weeks
Proton pump inhibitors dangerous or not?
Sometimes Proton pump inhibitors may leads to death risk
According to a study in July 3, 2017
Popular heartburn drugs known as Proton pump inhibitors may raise the chance of death what is the new research shows it is not the first time the drugs also known as Proton pump inhibitors have been linked to death dangerous
Which is better H2 blocker on proton pump inhibitor?
Proton pump inhibitor more effective than H2 blocker because there more often to use to treat chronic symptoms of heartburn so the protons pump inhibitors are best for use rather than H2blockers
Is Dexilant better than Omeprazole?
Dexilent dexlansoprazole is a effective medicine which is used to treat heartburn but it can be very expensive since it is only available as a brand
Treats heartburn and excess release of stomach acid secretion
Prilosec omeoprazole gives you the long lasting heartburn relief but it generally has some risks if used it for long time