Acyclovir: Do you want to know more about Acyclovir? Here we have discussed everything about Acyclovir’s Side effect, doses, uses and many more.
- The drug Acyclovir is generally known as the generic name for Zovirax
- This drug(Acyclovir)is used as an antiviral medication
- General information regarding Acyclovir
History of Acyclovir
Uses of Acyclovir
Acyclovir is primarily used the drug for the treatment of herpes, simplex virus infections chickenpox and shingles.
Other uses of Acyclovir
The other uses of acyclovir are the prevention of cytomegalovirus infections following grafting and help complications of Epstein Barr virus infection
Mode of Administration
The acyclovir tablet can be applied by mouth and is also can be applied as a cream to the skin and it also can be injected.
Acyclovir is used for the treatment of viral infections that are caused by the virus called varicella
This virus also causes the infection of chickenpox and shingles.
How does this drug works?
The drug Acyclovir prevents the virus from dividing and multiplying and it also stops the spreading of the herpes virus in the body. It may not cure genital herpes and may not stop the spreading of genital herpes to other people.
Mechanism of action of Acyclovir
The followings are the mechanism of action of Acyclovir.
Acyclovir is converted to its triphosphate form which is acyclovir triphosphate (ACV-TP) and later acyclovir completely inhibits the viral DNA polymerase, incorporates into and after it terminates the growth of viral DNA chain and at last this drug(Acyclovir)inactivates the viral DNA polymerase.
Formation and availability of Acyclovir
Acyclovir is made by GlaxoSmithKline and it is available in many forms such as tablets, capsules and liquid form Acyclovir is the drug which is used as the oldest and first-line drug for viral infections.
The dosage form of Acyclovir
Normal dose: 200mg in every 4 hours or 400mg in every 12 hours and crcl <10ml/min/1.73m decrease to 200mg in every 12 hours and 800mg in every 4 hours and crcl 10-25ml/min/1.73m2 decrease to 800mg/8 hour.
Usual route/dose is 10mg Or 20mg per kg (4.5 to 9.1mg/pound) of body weight injected slowly into a vein over at least a one hour and this process is repeated in every 8 hours for 7-10days.
How long does it take to work in the body?
Acyclovir takes 2 hours to reach a peak plasma concentration after oral administration, it takes up to 3 days for the reduction of symptoms, however, it should be taken until the course prescribed by the doctor as completed
Acyclovir works best within 48 hours of onset.
Side effects of Acyclovir
The side effects are as follows:
- Muscle or joint aches
- Visual changes
- Abdominal pain
- Anemia (low iron level in the body)
- Ataxia (it is a condition that causes loss of control over body movement)
Warnings for acyclovir
- The only way is acyclovir tablets, capsules and suspensions are applied for oral ingestion only
- It may cause renal failure in some cases and sometimes it leads to death and this is an observation that made with acyclovir Therapy
- Some important observations during clinical practice and overdose) that is thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), it leads to death and it is seen that this has occurred in immunocompromised patients those are undergoing in acyclovir therapy